Well, assuming you mean the first time you fight Ansem on Destiny Islands, and not when you fight him near that airship-thingy, just stay as far away from him as you can and attack with Strike Raid. Whenever Ansem yells out "Submit", his guardian will come out and try to grab you. Dodge roll and get the hell away from him. Ansem will also shoot these orbs at you, which you can deflect back at him by using guard, or you can just dodge roll. Just equip your best weapons and accessories and heal whenever needed. ^_^
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